2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1984S
    p,p'-DDD-d8 93952-20-6 98%
    p,p'-DDD-d8 is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats.
    p,p'-DDD-d8
  • HY-B2073A
    Clocapramine dihydrochloride hydrate 60789-62-0 98%
    Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors.
    Clocapramine dihydrochloride hydrate
  • HY-B2121R
    6-Methoxy-2-naphthoic acid (Standard) 2471-70-7
    6-Methoxy-2-naphthoic acid (Standard) (6-MNA (Standard)) is the analytical standard of 6-Methoxy-2-naphthoic acid (HY-B2121). This product is intended for research and analytical applications. 6-Methoxy-2-naphthoic acid (6-MNA) is the active metabolite of Nabumetone (HY-B0559). 6-Methoxy-2-naphthoic acid is also an inhibitor of COX-1 and COX-2. 6-Methoxy-2-naphthoic acid can inhibit the synthesis of gastric mucosal prostaglandin E2. 6-Methoxy-2-naphthoic acid can be used in the research of inflammation and pain-related diseases. In addition, 6-Methoxy-2-naphthoic acid is an impurity in Naproxen (HY-15030) and can also be used in the synthesis of other active compounds.
    6-Methoxy-2-naphthoic acid (Standard)
  • HY-B2177R
    Apronal (Standard) 528-92-7
    Apronal (Standard) is the analytical standard of Apronal. This product is intended for research and analytical applications. Apronal (Allylisopropylacetylurea, Apronalide) can bu used for the research of neuropsychiatry disorders.
    Apronal (Standard)
  • HY-B2229R
    Sulbutiamine (Standard) 3286-46-2
    Sulbutiamine (Standard) is the analytical standard of Sulbutiamine. This product is intended for research and analytical applications. Sulbutiamine is a synthetic analogue of vitamin B1 used for the treatment of asthenia.
    Sulbutiamine (Standard)
  • HY-B2233A
    Calcium phosphorylcholine chloride, 98% 4826-71-5 98%
    Calcium phosphorylcholine chloride, 98% is the main phospholipid component in eukaryotic biofilms. Calcium phosphorylcholine chloride, 98% exists in commensal or pathogenic bacteria associated with eukaryotes in prokaryotes. Calcium phosphorylcholine chloride, 98% exhibits a surprising range of immunomodulatory properties.
    Calcium phosphorylcholine chloride, 98%
  • HY-D0004R
    Azure B (Standard) 531-55-5
    Azure B (Standard) is the analytical standard of Azure B. This product is intended for research and analytical applications. Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects.
    Azure B (Standard)
  • HY-D0187B
    L-Glutathione reduced monosodium 20167-21-9 98%
    L-Glutathione reduced monosodium is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.
    L-Glutathione reduced monosodium
  • HY-D0195R
    Acesulfame potassium (Standard) 55589-62-3
    Acesulfame (potassium) (Standard) is the analytical standard of Acesulfame (potassium). This product is intended for research and analytical applications. Acesulfame potassium is an artificial sweetener. Acesulfame potassium (long-term) affects cognitive functions, potentially via altering neuro-metabolic functions in mice.
    Acesulfame potassium (Standard)
  • HY-D0914A
    Fast green FCF free acid 25738-40-3 98%
    Fast green FCF free acid is a dye that is acid-resistant. Fast Green FCF free acid inhibits α-synuclein aggregation, as well as Aβ, P2X4 receptor and TLR4/Myd88/NF-κB. Fast Green FCF free acid is widely used as a staining agent like quantitative stain for histones at alkaline pH after acid extraction of DNA, and as a protein stain in electrophoresis. Fast Green FCF free acid improves cognitive impairment, depression, relieves pain allergies, and promotes reproductive function.
    Fast green FCF free acid
  • HY-D0924A
    Cy5.5 acetate 98%
    Cy5.5 acetate is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
    Cy5.5 acetate
  • HY-D0924B
    Cy5.5 TEA 98%
    Cy5.5 TEA is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis. CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance.
    Cy5.5 TEA
  • HY-D2844A
    FITC-PEG-FA (MW 1000) 98%
    FITC-PEG-FA (MW 1000) is a fluorescent dye composed of Folic acid (HY-16637) (FA), polyethylene glycol (PEG) and FITC (HY-66019). Fluorescent dye is linked to PEG and Folic acid through a specific chemical reaction to form a molecule with special properties. FITC-PEG-FA (MW 1000) can be used for fluorescent labeling and imaging.
    FITC-PEG-FA (MW 1000)
  • HY-D2844B
    FITC-PEG-FA (MW 2000) 98%
    FITC-PEG-FA (MW 2000) is a fluorescent dye composed of Folic acid (HY-16637) (FA), polyethylene glycol (PEG) and FITC (HY-66019). Fluorescent dye is linked to PEG and Folic acid through a specific chemical reaction to form a molecule with special properties. FITC-PEG-FA (MW 2000) can be used for fluorescent labeling and imaging.
    FITC-PEG-FA (MW 2000)
  • HY-D2844D
    FITC-PEG-FA (MW 5000) 98%
    FITC-PEG-FA (MW 5000) is a fluorescent dye composed of Folic acid (HY-16637) (FA), polyethylene glycol (PEG) and FITC (HY-66019). Fluorescent dye is linked to PEG and Folic acid through a specific chemical reaction to form a molecule with special properties. FITC-PEG-FA (MW 5000) can be used for fluorescent labeling and imaging.
    FITC-PEG-FA (MW 5000)
  • HY-D2844E
    FITC-PEG-FA (MW 10000) 98%
    FITC-PEG-FA (MW 10000) is a fluorescent dye composed of Folic acid (HY-16637) (FA), polyethylene glycol (PEG) and FITC (HY-66019). Fluorescent dye is linked to PEG and Folic acid through a specific chemical reaction to form a molecule with special properties. FITC-PEG-FA (MW 10000) can be used for fluorescent labeling and imaging.
    FITC-PEG-FA (MW 10000)
  • HY-E70049
    beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) 67338-98-1 98%
    beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) (GM2/GD2 synthase) is a key enzyme which catalyzes the conversion of GM3, GD3 and lactosylceramide (LacCer) to GM2, GD2 and asialo-GM2 (GA2), respectively. beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) is a key enzyme to control the synthesis of brain-enriched complex gangliosides.
    beta-1,4-N-Acetylgalactosaminyltransferase (CgtA)
  • HY-E70149
    ST6 Gal Sialyltransferase 2 98%
    ST6 Gal Sialyltransferase 2 (EC:2.4.3.1, ST6GAL2) catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. ST6 Gal Sialyltransferase 2 plays an important role in schizophrenic research.
    ST6 Gal Sialyltransferase 2
  • HY-E70172
    Heparan Sulfate 3-O-Sulfotransferase 4 98%
    Heparan Sulfate 3-O-Sulfotransferase 4 is a sulfotransferase. Heparan Sulfate 3-O-Sulfotransferase 4 regulates Notch signaling.
    Heparan Sulfate 3-O-Sulfotransferase 4
  • HY-E70294
    N-Acetylgalactosaminyltransferase 13 98%
    N-Acetylgalactosaminyltransferase 13 (GALNT13) is a glycosaminyltransferase. N-Acetylgalactosaminyltransferase 13 participates in neuronal differentiation by glycosylating and stabilizing PDPN.
    N-Acetylgalactosaminyltransferase 13
Cat. No. Product Name / Synonyms Application Reactivity